Relations between Belarus and Iran have stirred up controversies concerning their alleged anti-American character. Yet, the Belarusian leadership has avoided making serious anti-American gestures with Tehran doing its best to alleviate Western concerns in this regard. The chosen course of relations has demonstrated the limits of defiance to the international system. Both Minsk and Tehran cannot ignore the counteractions of their opponents, especially the United States, to this cooperation. With the emergence of a unipolar world, changes in global international structures and the rising influence of the United States have all defined the general dynamics of Belarus-Iranian relations. Domestic factors, such as the state’s own general capacities, have shaped this relationship considerably less.